So, I upgraded Studio One and Melodyne, both to v4.1, and when I open Melodyne I'm not getting any of the glitches or bugs that have been reported as per GUI, crashes, etc., that some people have reported, mainly on OSX but some on WIN as well (see below link,) but I'm getting a popup that is telling me that I need to update to the latest version of Melodyne.
This is actually far more confusing than any bugs or glitches since I have the newest update, everything else is working fine and seems to have installed correctly and as far as I can tell, no one else has encountered this problem.
I just thought someone might be able to shed some light on this. Thanks.

https://answers.presonus.com/28957/bug-report-melodyne-4-studio-in-studio-one-4-not-working

 

I got this problem with S1 v4.0 but now melodyne works for me with v4.1.I don't know why.
You can still download Melodyne seperatly and use it as an insert FX.
Win10 pro

 

I doubt it matters, but I'm on WIN7Ult.x64.

 

I've tried everything that I can think of and it's still bust. Anyone have any ideas?

 

I tried that. It says it's not compatible and I need to update Melodyne to the latest version....

 

Sorry,I don't know why you have this problem...
Maybe try to clean with the windows on board text editor the files in "users/your name/AppData/Presonus/Studio One4/x64".
If it doesn't work uninstall and re-install after you delete all the files in "AppData/Presonus",but don't delete "user devices",they are your external controllers/instruments that you configured.

The problem is probably in this "AppData/Presonus" folder.